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The world’s first-ever gene therapy clinical trial in patients with advanced Parkinson’s disease significantly reduced their symptoms, suggesting surgery to deliver a modified gene directly to the brain could be a safe new treatment option for a number of neurodegenerative diseases.
A study suggests that acute leukemia patients whose cancer cells show a genetic change that usually predicts a swift return of the disease following remission may remain disease-free longer when given aggressive therapy. The findings apply to people with acute myeloid leukemia (AML) whose cancer cells have normal-looking chromosomes and a gene mutation called MLL-PTD.
Scientists have identified a potential therapeutic target in muscles for the treatment of Duchenne muscular dystrophy, the most common form of the progressive disease. The study confirmed that a particular protein is responsible for the chronic inflammation and muscle-cell death that are hallmarks of Duchenne muscular dystrophy.
A newly instituted screening test performed on all colon cancer patients at the Ohio State University Medical Center’s James Cancer Hospital and Solove Research Institute may be key to detecting a hereditary cancer syndrome that puts people at high risk for tumors of the colon, endometrium, stomach and ovaries.
Web sites that use family medical history to help estimate a person’s risk of developing cancer should be improved to reach a more diverse audience and should take a more comprehensive view of family cancer history, according to a recent study by Ohio State University cancer researchers.
On the surface, the two women, both in their early 60s, appeared to have the same disease: early stage, estrogen receptor positive breast cancer, and until recently, they probably would have received the same treatment. But oncologists are increasingly using a new gene assay that helps predict how aggressive a tumor really is – and how likely it is the cancer will recur.
